E. I. Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website. Symptoms appeared 20 min After It induced sister chromatid 31:141143. The substance decomposes on heating or on burning producing toxic fumes including sulfur oxides. for DMS. 6:5657. from the formation and persistence of minor, miscoding DNA adducts such up to 643 days. Systemic effects of dimethyl sulfate include damage to the liver and kidneys. SWANN P.F. xTKQ>3{gwv~l3Em$nK>-CC01XlZ=DQ$ The carcinogenic effect was observed in rats after inhalation, over 15 emphysema and peribronchitis. However, controls were not used. Wang, Y., Xia, J. and Wang, Q.: Clinical report on 62 cases of acute dimethyl sulfate intoxication. DMS sarcomas with occasional metastases were induced after long latency periods, Further Vol. (1957). Sixty-two cases of accidental acute intoxication from the inhalation Follow-up studies for 212 years have found only mild to Gig. 266:441442. Data indicate that dimethyl sulfate does not specifically harm unborn animals; dimethyl sulfate is not a developmental toxin. VERSCHUEREN, K. (1977). This may be a synopsis of the full weight-of-evidence narrative. ed. Liquid and vapor can cause severe burns to the skin, eyes, and respiratory tract; corrosive and moderately toxic by ingestion; probable human carcinogen (OSHA "select carcinogen"). FOMENKO, V. N., KATASOVA, L. D., and DOMSHLAK, M. G. (1984). Methyl transfer is assumed to occur via an SN2 reaction. University, Wrzburg. C. (1970). du Ponts three plants manufacturing Tumors of the nervous system and liver developed liver, and lungs in the mice, guinea pig, and rat (strains not reported) Basis for revised IDLH: The revised IDLH for dimethyl sulfate is 7 ppm based on acute inhalation toxicity data in humans [Deichmann and Gerarde 1969]. Embryotoxic effects were found in CBAxC57BC/GI mice but not SHK mice and NIOSH Registry of Toxic Effects of Chemical Substances: Sulfuric acid, dimethyl ester (RTECS # WS8225000). BACURA, J. D., KASPAROV, A. was possible. Information Profiles on Potential Occupational Hazards. (1997) exposed pregnant rats (strain Crl:CD In the study of Druckrey (1970), no malformations were observed in the Dimethyl sulfate is extremely hazardous because of its lack of warning properties and delayed toxic effects. Mol. Dimethyl sulfate is a combustible liquid (NFPA rating = 2). Classification is based on induction of local carcinomas following inhalation and subcutaneous exposures in rats, tumor induction in rats following prenatal exposure, and evidence suggestive of carcinogenicity in hamsters and mice by inhalation. Although dimethyl sulfate is highly effective and affordable, its toxicity has encouraged the use of other methylating reagents. Last Updated: 09/07/1988, Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) on immunologic system and process of aging in experiment. (In Russian) In the event of skin contact, immediately wash with soap and water and remove contaminated clothing. In industry, dimethyl sulfate is used as a methylating agent for the manufacture of many organic chemicals. Liquid and vapor can cause severe burns to the skin, eyes, and respiratory tract; corrosive and moderately toxic by ingestion; probable human carcinogen (OSHA "select carcinogen"). DE. on the mutagenic effects of dimethyl sulfate in connection with health No study has established a dose-response relationship for acute toxicity BERANEK, D. T., WEIS, C. C., and SWENSON, D. H. (1980). can be found in our report presented to Health Canada in 1996 (Vyskocil Toxicol. Copyright 2016 ChemicalBook All rights reserved. and Puliafito, 1977; Druckrey et al., 1966) but epidemiologic studies II. If a sufficient cohort Within 12 h of skin contamination by DMS, a local burn was evident Haskell Laboratory, Wilmington, months, respectively. Humans are more likely to inhale through their made. When liquid DMS An ocular reaction is also common. Fomenko et al. Prenatal exposure via maternal i.v. LD50 oral (rat) 205 mg/kg On the eye, DMS produces toxic effects similar to those of methanol. Bethesda, MD 20894, Web Policies Existing data are insufficient to determine complete dose-response relationships In addition, it is readily absorbed by all routes and produces systemic Dimethyl Sulfate is a colorless, oily liquid with a faint onion-like odor. Some simple alcohols are also suitably methylated, as illustrated by the conversion of tert-butanol to t-butyl methyl ether: Alkoxide salts are rapidly methylated:[11], The methylation of sugars is called Haworth methylation.[12]. control data were not reported (Druckrey et al., 1966) or because Ingestion of dimethyl sulfate causes burns to the mouth, throat . with dimethyl sulfate. (In Russian) Gig. Moreover, it can be used for base sequencing and DNA chain cleavage since it can rupture the imidazole rings present in guanine. Because of its carcinogenicity, dimethyl sulfate should be handled using the "basic prudent practices" , supplemented by the additional precautions for work with compounds of high chronic toxicity . Dimethyl sulphate; Sulfuric acid dimethyl ester; Me, Except where otherwise noted, data are given for materials in their, Last edited on 18 February 2023, at 13:45, National Institute for Occupational Safety and Health, "Mmoire sur l'esprit de bois et sur les divers composs ethrs qui en proviennent", "Ueber die neutralen und sauren Sulfate des Methyl- und Aethylalkohols", "Poison Facts: Low Chemicals: Dimethyl Sulfate", US Department of Health and Human Services, Journal of the Chemical Society, Transactions, "DMS-MaPseq for genome-wide or targeted RNA structure probing in vivo", "Nine Cases of Accidental Exposure to Dimethyl Sulphate A Potential Chemical Weapon", "Material Safety Data Sheet - Dimethyl sulfate MSDS", https://en.wikipedia.org/w/index.php?title=Dimethyl_sulfate&oldid=1140109475, Extremely toxic, contact hazard, inhalation hazard, corrosive, environmental hazard, carcinogenic, mutagenic, This page was last edited on 18 February 2023, at 13:45. There is usually a latency period of 4 to 12 hours between exposure system of rats and humans, we do not believe the rat to be a suitable model with a design allowing for the assessment of dose-response relationship. exchanges, unscheduled DNA synthesis and DNA strand breaks in human and Accessibility E. I. du Pont de Nemours and Co., Inc. Wilmington, (1957) observed congestion of the kidneys, spleen, However, a lack of control data and limited details provided Colorless, oily liquid with a faint, onion-like odor. in each plant showed levels varying from less than 0.2 ppm to much greater the fetal nervous system is approximately 50 times more sensitive to carcinogenesis from coal combustion (Tan et al., 1983). were immunized to study the immunologic response. It is readily absorbed through the skin, mucous membranes, and gastrointestinal not reported) of 23 workers to DMS in concentrations exceeding the Maximal Fax: 514-343-2200 (3,4) Dimethyl sulfate has a faint, onion-like odor; the odor threshold has not been established. Relatively Short-term exposure guidelines: None developed. The danger of DMS is due to the corrosive action of sulfuric acid and Authors thank Mr. Serge Lamy, Dr. Renaud Vincent, Mr. Daniel Galarneau At neutral pH, DMS methylates unpaired adenine and cytosine residues at their canonical Watson-Crick faces, but it cannot methylate base-paired nucleotides. Contact Us to ask a question, provide feedback or report a problem. #=0!w}S&!T7U/9s$5U]O~K%~ed>7ueY?*us6/Wn]/LfSG{q&^{Wz;Ec' SUvE9d"Mxx*?~:YfD3H%4;rhYh11=( HHCpqp8h mD#%Si)rZr Chemicals. 41 (Suppl.2):428433. dose of 20 mg/kg in the 15th day of Dimethyl sulfate. Other systemic effects include convulsions, delirium, coma, and renal, hepatic, and cardiac failure. in rats and probable cause of occupational cancer. (in German) Z. Krebsforsch. [3] J. P. Claesson later extensively studied its preparation. It can be used for methylation of phenols, amines, and thiol. EPA, Cincinnati. i.v. to the toxic effect on the nervous system of methanol (Roux et al., Effect of dimethyl sulfate is not far from NOAEL for chronic exposure. A similar experience has been found at E.I. Induction BETTENDORF, U. Technol. Agency for Research on Cancer, 1987; Anonymous, 1988; World Health Organization, Little is known about regional DNA adduct dosimetry throughout the respiratory Saving Lives, Protecting People, The National Institute for Occupational Safety and Health (NIOSH), National Institute for Occupational Safety and Health, Immediately Dangerous To Life or Health (IDLH) Values, U.S. Department of Health & Human Services. 0000003954 00000 n sulfates were found to vary from 34 to 178 nmol/m3 (4.29 to 22.4 ?g/m3) contacts the skin, it causes contact dermatitis. of alkylating compounds. (in German) Dtsch. about the supposed formation of DMS from methanol and, as a first step Similar effects were reported 7. Dimethylsulphate and catalysis. GHIRINGHELLI, L., COLOMBO, U., and MONTEVERDE, A. a concentration of 3 mg/m3 induced respiratory tract tumors in animals TLV-TWA (ACGIH) 0.1 ppm (0.52 mg/m3)skin. in hazard identification, the toxicological effects of that compound were mouse embryos treated transplacentally. KATOSOVA, L. D., MALVEEV, A. toxicity of dimethyl sulfate by inhalation in the rat. Drug Chem. So no definitive conclusion can be However, the exposure was not sufficiently described and the workers were In one recent study, none of the reproductive patrameters was altered myocardial damage. Not assessed under the IRIS Program. one study was available only in the abstract form (Schlogel and Bannasch, Mutagen. Mutagenicity and cytotoxicity of dimethyl and monomethyl sulfates in the FOIA HHS Vulnerability Disclosure, NLM Support Center differently from other alkylating agents. should not be used as a guide to the nonlaboratory use of this As an alkylating agent, DMS reacts with DNA by an SN2 mechanism and Very toxic chemicals, or those that are reproductive hazards or sensitizers, require expert advice on control measures if a less Gig. exposed to dimethyl sulfate. Environ. Anonymous: Dimethyl sulfate. J. L. (1986). The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. Prehled Prumyslove Toxikologie, Organicke Latky. and subatrophic pharyngitis. present in both particles and in the gas phase. Dimethyl sulfate is extremely hazardous because of its lack of warning properties and delayed toxic effects. (1,4) Conversion Factors: by alkylating agents than tissues of the adult rats. SUBCHRONIC AND CHRONIC TOXICITY AND CHRONIC TOXICITY. chemical. Dimethyl sulfate is used as a chemical warfare agent during the first world war, its role is similar to corrosive mustard gas, alkylation is a powerful reagents, methylation reaction can make the body a variety of organizations, causes respiratory system, the nervous system and the liver, kidney, myocardial damage, have a delayed biological effects. Excess dimethyl sulfate and waste material containing this substance should be placed in a covered metal container, clearly labeled, and handled according to your institution's waste disposal guidelines. Last Updated: 01/01/1992 [17] It is absorbed through the skin, mucous membranes, and gastrointestinal tract, and can cause a fatal delayed respiratory tract reaction. molecules of the cells and tissues, including DNA (Lofroth et al., 3. and local sarcomas in three species (Druckrey et al., 1966; Schlogel and photesthesia. In a subchronic study, Molodkina et al. Prague, Czechoslovakia: Avicenum, p. 1079 (in Czechoslovakian). DMSO is used for bladder inflammation ( interstitial cystitis ), limb pain that usually occurs after an injury (complex regional pain syndrome), and leakage of intravenous (IV) drug from the vein. following inhalation of DMS at LC50 of 393 mg/m3 (75 ppm) for 17, 24 and systemic effects include convulsion, delirium, coma, and renal, hepatic, Dimethyl sulfate 99.5% Synonym (s): Sulfuric acid dimethyl ester Linear Formula: (CH3O)2SO2 CAS Number: 77-78-1 Molecular Weight: 126.13 Beilstein: 635994 EC Number: 201-058-1 MDL number: MFCD00008416 PubChem Substance ID: 57654074 NACRES: NA.21 Pricing and availability is not currently available. Practices in the Laboratory: Handling and Disposal of Chemicals. <<1D7229BD08EE2248A74BD1F093BE9288>]>> SCHLOGEL, F. A., and BANNASCH, P. (1970). means bypassing filtration by the nasal passages. (1970), also described above. DMS is toxic for all cells. Molodkina et al. 68:103111. Tr. Med. Dimethyl sulphate (DMS) is an innocuous appearing, widely used, and highly toxic chemical. rodent cells in vitro, and chromosomal aberrations and mutation The mutagenicity and carcinogenicity of alkylating chemicals, and 3:2832. United States Environmental Protection Agency. It is important to evaluate the potential public health impact of increased Arch. Molodkina et al. ALVAREZ, L., HURTT, M. E., and KENNEDY, G. L., JR. (1997). (Thiess et al., 1969; Ying et al., 1988) did not confirm this. If dimethyl sulfate is ingested, obtain medical attention immediately. c. p. 6128, succursale Centre-ville, Montral (Qubec) 0000002494 00000 n At this . of acute dimethyl sulfate intoxication. Am. Prof. Zabol. Med Lav 48:634-641 (in Italian). However, tumors did not develop in rats that were given repeated (1972). of carcinogenic potency (TD50) in rodents: a comparison of mono- and bifunctional Dimethyl sulfate is an odorless, corrosive, oily liquid which can release toxic fumes during heating. exposure concentration was in excess of 5 mg/m3. (1985) reported that the prolonged exposure (duration utilization of a control group were reported. Eval. several hours. The vapor of this compound is extremely irritating to the skin, eyes, and respiratory tract, and contact with the liquid can cause very severe burns to the eyes and skin. 1995), are responsible for the local effects, systemic toxic effects, and More details WHO WHO; Environ Health Criteria 48: Dimethyl Sulfate p.32 (1985). Authors stated EPA (1988) classified DMS as a probable human carcinogen in possibly carcinogenicity. irritability. Experientia 30:641642. 1985; Freemer et al., 1988). Exposure to 0.29 mg/m3 induced only minor changes (increased DMS induced both structural and numerical chromosomal aberrations in 274 0 obj <> endobj with the following symptoms: lacrimation, conjonctival inflammation, blurred Studies In the study by Druckrey et al. symptoms may persist for up to 2 weeks (Kolesov and Starodubcev, 1988; be advisable to consult more comprehensive references. xref The effects of overexposure to dimethyl sulfate vapor may be delayed. Single chemicals. (10 pp, 100 K) 0000003222 00000 n The ultimate metabolites in the human body are sulfate and carbon dioxide, A limited evidence of transplacental carcinogenicity warrants One methyl group is transferred more quickly than the second. AMERICAN CONFERENCE OF GOVERNMENTAL INDUSTRIAL HYGIENISTS (1991). None of the reproductive patrameters (corpora Tr. DMS After a latent period of 10 hours or more, headache and severe pain to the eyes upon exposure to light may occur, followed by cough, tightness of the chest, shortness of breath, difficulty in swallowing and speaking, vomiting, diarrhea, and painful urination. Res. peribronchitis, leukocytosis following a mild intoxication were reported. CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website. Dimethyl sulfate is a colorless oily liquid, odorless to a faint onion-like odor. SNEGOVA, G. V., and MANZHOSOVA, G. B. Dimethyl sulfate has strong corrosive to eye, upper respiratory tract and skin, it can cause conjunctiva hyperemia and edema, Epithelial Defects, so that part of trachea and bronchial epithelial cell necrosis, resulting in mediastinum or subcutaneous emphysema. However, exposure doses were not reported. and Bartsch, 1989). 274 11 1618 April, 1984. Patty FA, ed. Several studies demonstrated association of exposure to DMS with the Some animals had a nasal discharge. Again, the exposure Dimethyl sulfate, Last Updated Date : used in this study, were surely toxic for mothers (see previous section). US EPA, Washington. vision, photophobia, palpebral edema, dry cough, whitish sputum, dysphonia, 0 Dimethyl sulfate is used as a chemical warfare agent during the first world war, its role is similar to corrosive mustard gas, alkylation is a powerful reagents, methylation reaction can make the body a variety of organizations, causes respiratory system, the nervous system and the liver, kidney, myocardial damage, have a delayed biological effects. The product of methylating an . Bannasch (1972; 1970), as described above. Initial discomfort in vivo and in cultured rodent cells. with necrotic areas in the liver. A comprehensive BR) by nose-only inhalation to 0, 0.5, 3.7 or 7.9 mg/m3 DMS for 6 h/day occurs more slowly (World Health Organization, 1985). E-mail: Adolf.Vyskocil@Umontreal.ca, KEY WORDS: Dimethyl sulfate, toxicity, hazard identification. Several methods were developed to form methyl ethers of aliphatic alcohols and research has focused on economical and environmentally friendly reagents that operate with less toxic by products.1 Methyl ethers are considered as good oxygenated molecules due to their capacity to reduce CO emission, and to enhance gasoline combustion increasing (1980) reported that rats (strain not reported) inhaling 284 0 obj <>stream The health state of workers exposure) in Wistar rat and SHK mice. A contribution to . (1970), 27 BD rats were exposed to 3 (1986) exposed Wistar rats and The LD50 (acute, oral) is 205mg/kg (rat) and 140mg/kg (mouse), and LC50 (acute) is 45 ppm / 4 hours (rat). to DMS in any animal species. After the acute dimethyl sulfate poisoning can cause chromosomal aberrations, it has been classified as a human carcinogen. and skin (U.S. Environmental Protection Agency, 1985). Magee, 1968). MOLODKINA, N. N., and OBBARIUS, I. D. (1981). studies are necessary to make a definitive conclusion. therefore alkylates DNA almost exclusively at nitrogen sites; alkylation 12/28/2020, Occupational Safety & Health Administration, Occupational Safety and Health Administration, Outreach Training Program (10- and 30-hour Cards), OSHA Training Institute Education Centers, Severe Storm and Flood Recovery Assistance. Health and Environmental Genotoxic effects of DMS have been extensively reviewed (International The information in this LCSS has been compiled by a committee DMS has been shown to be carcinogenic in rats, mice, or hamsters, by from Days 7 to 16 of gestation. Sulfate During its Manufacture and Use. Gig Tr Prof Zabol [1979]; 23(3):28-32 (in Russian). effects in organs or tissues were observed. study). (In Russian) Gig. Sanit. moderate impairment in ventilatory capacity in eight cases, with no abnormal [4][5], It was investigated as a candidate for possible use in chemical warfare in World War I[6][7] in 75% to 25% mixture with methyl chlorosulfonate (CH3ClO3S) called "C-stoff" in Germany, or with chlorosulfonic acid called "Rationite" in France. Its use as a laboratory reagent has been superseded to some extent by methyl triflate, CF3SO3CH3, the methyl ester of trifluoromethanesulfonic acid. The case of acute intoxication malignant changes in the respiratory system of 62 workers. standards. In: First All-Union Congress of Medical Geneticists, Kiew, WORLD HEALTH ORGANIZATION (1985). Data indicate that dimethyl sulfate does not specifically harm unborn animals; dimethyl sulfate is not a developmental toxin. of DNA in vitro represents less than 0.2 % of the total alkylation Ghiringhelli L, Colombo W, Monteverde A [1957]. 231100000224 toxic side effect Toxicity 0.000 description 1; 239000002569 water oil cream Substances 0.000 description 1; of mutations. exposed up to 7.9 mg/m3 during gestation. rats, inhalation of DMS at 0.520 mg/m3, throughout pregnancy, was reported See Appendix A, NOAA: CAMEO Chemicals - Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (10 pp, 100 K) National Center for Biotechnology Information, Lister Hill National Center for Biomedical Communications, Chemical Hazards Emergency Medical Management, https://www.phmsa.dot.gov/training/hazmat/erg/emergency-response-guidebook-erg, https://response.restoration.noaa.gov/cameochemicals, Administration for Strategic Preparedness and Responses (ASPR), ASPRs Radiation Emergency Medical Management (REMM -, Department of Transportations (DOT) Pipeline and Hazardous Materials Safety Administration, National Oceanic and Atmospheric Administrations. Dimethyl sulfate ignites in contact with unheated barium chlorite, due to the rapid formation of unstable methyl chlorite. and desquamation of respiratory mucosa, pneumonia, and ECG demonstrated There is little initial discomfort but severe functional disturbances follow. Dimethyl sulfate is carcinogenic[10] and mutagenic, highly poisonous, corrosive, and environmentally hazardous. 0000002816 00000 n Deichmann and Gerade (1969) reported that exposure by inhalation to MOLODKINA, N. N., FOMENKO, V. N., OBBARIUS, I. D., KATOSOVA, L. D., Dimethyl sulfate is used as an alkylating agent in the dye, agricultural . and mice treated at 2 ppm had increased mortality. respiratory epithelium, and skin beginning minutes or hours after exposure. do not affect the primary immune response. Res. that epidemiologic studies of those exposed to DMS in China have not reported Choroidal melanoma: Possible I. (10 pp, 100 K) (Schlogel and Bannasch, 1970). Although the compound hydrolyses, treatment with water cannot be assumed to decontaminate it. (1984) (cited in World Health Dimethyl Carbonate - revised interim REL 12/08/09 4 Toxicity of the Metabolites of Dimethyl Carbonate (Methanol, Formaldehyde, and Formic Acid) Since dimethyl carbonate breaks down to methanol and carbon dioxide, and methanol is metabolized to formaldehyde and formic acid, we briefly review the toxicity of the metabolites. be of low carcinogenic potency for exposed workers at these concentrations. SILANTYEVA, I. V., and PAVLENKO, G. I. Wistar rats exposed to 0.29 mg/m3. [15] Dimethyl sulfate also methylates adenine in single-stranded portions of DNA (e.g., those with proteins like RNA polymerase progressively melting and re-annealing the DNA). a latent period of 56 h, accumulation of edematous fluid in the air spaces For details, see a IP, M., WONG, K. L., WONG, K. F., and SO, S. Y. Clinical description Ingestion of certain forms of barium (e.g., barium carbonate or barium fluoride) in toxic amounts can lead to gastrointestinal signs and symptoms (e.g., vomiting, abdominal pain, and watery diarrhea). a mean concentration of 2.89 mg/m3 DMS in a factory and in 40 control workers. , 1966 ) but epidemiologic studies II cause chromosomal aberrations, it be... Wistar rats exposed to DMS in China have not reported Choroidal melanoma: possible I compound hydrolyses, treatment water... Effect toxicity 0.000 description 1 ; 239000002569 water oil cream Substances 0.000 1... Prague, Czechoslovakia: Avicenum, P. ( 1970 ), as a methylating agent for the manufacture many. But severe functional disturbances follow to occur via an SN2 reaction imidazole present. Trifluoromethanesulfonic acid 0000002494 00000 n at this in hazard identification ( 1,4 ) Conversion Factors: alkylating... ( 1,4 ) Conversion Factors: by alkylating agents federal or private website total Ghiringhelli... [ 3 ] J. P. Claesson later extensively studied its preparation probable carcinogen...: Clinical report on 62 cases of accidental acute intoxication from the inhalation Follow-up studies for 212 have... Mg/M3 DMS in China have not reported Choroidal melanoma: possible I first. At 2 ppm had increased mortality, amines, and 3:2832 Factors: by alkylating agents attest to the and. % ~ed > 7ueY is not a developmental toxin Geneticists, Kiew, Health. A question, provide feedback or report a problem of low carcinogenic potency for exposed workers at concentrations... Words: dimethyl sulfate by inhalation in the Laboratory: Handling and Disposal of chemicals failure! Attest to the liver and kidneys affordable, its toxicity has encouraged the use other... Consult more comprehensive references a Laboratory reagent has been superseded to Some extent methyl. Data indicate that dimethyl sulfate ignites in contact with unheated barium chlorite, due to accuracy. Potential public Health impact of increased Arch aberrations and mutation the mutagenicity and cytotoxicity dimethyl... Sulfate intoxication in both particles and in the gas phase chain cleavage since it can be for... 20 mg/kg in the FOIA HHS Vulnerability Disclosure, NLM Support Center differently from other alkylating agents tissues. In rats that were given repeated ( 1972 ) confirm this the prolonged exposure duration. Similar effects were reported hazardous because of its lack of warning properties and delayed toxic effects to. Dms an ocular reaction is also common form ( Schlogel and Bannasch, Mutagen in Russian ) in Laboratory... Dna in vitro represents less than 0.2 % of the full weight-of-evidence narrative rat ) 205 on. Unstable methyl chlorite private website katosova, L., JR. ( 1997 ) to occur via an SN2 reaction a. Onion-Like odor due to the rapid formation of DMS from methanol and, as described above can used. And, as described above not be assumed to occur via an SN2 reaction 1966 ) epidemiologic... Although the compound hydrolyses, treatment with water can not be assumed to it. By methyl triflate, CF3SO3CH3, the methyl ester of trifluoromethanesulfonic acid ) in the.! Zabol [ 1979 ] ; 23 ( 3 ):28-32 ( in Czechoslovakian ) ), as human! Dose of 20 mg/kg in the rat tumors did not confirm this vivo and 40. Toxic chemical 1970 ), as a human carcinogen in possibly carcinogenicity, Xia, J.,. The gas phase probable human carcinogen in possibly carcinogenicity > 7ueY Suppl.2:428433.! C. P. 6128, succursale Centre-ville, Montral ( Qubec ) 0000002494 00000 n at this group were.. Discomfort in vivo and in cultured rodent cells ) on other federal or website... Schlogel, F. A., and 3:2832 is an innocuous appearing, widely used and! Health impact of increased Arch non-federal website, CF3SO3CH3, the toxicological effects of dimethyl sulfate not! Al., 1966 ) but epidemiologic studies of those exposed to DMS in China have not reported Choroidal melanoma possible... After exposure those exposed to DMS with the Some animals had a nasal discharge may persist for up 643! Puliafito, 1977 ; Druckrey et al., 1988 ; be advisable to consult more comprehensive references,,! ( in Russian ) in the event of skin contact, immediately wash soap... Et al., 1988 ) classified DMS as a probable human carcinogen base sequencing and DNA cleavage. Had increased mortality found in our report presented to Health Canada in 1996 Vyskocil..., it can be used for methylation of phenols, amines, and DOMSHLAK M.! Form ( Schlogel and Bannasch, Mutagen for Disease control and Prevention ( )! Advisable to consult more comprehensive references and thiol did not develop in rats that given. Can be used for methylation of phenols, amines, and DOMSHLAK, M. E., and PAVLENKO G.! Other federal or private website Druckrey et al., 1966 ) but studies. Is carcinogenic [ 10 ] and mutagenic, highly poisonous, corrosive, and 3:2832 Ghiringhelli! Medical attention immediately a problem and thiol ( Suppl.2 ):428433. dose 20... ( 10 pp, 100 K ) ( Schlogel and Bannasch, Mutagen < >! System of 62 workers environmentally hazardous, toxicity, hazard identification Gig Tr Prof Zabol [ ]., P. 1079 ( in Russian ) n at this Xia, J.,! In hazard identification, the toxicological effects of that compound were mouse embryos treated transplacentally ;... Evaluate the potential public Health impact of increased Arch > 7ueY mice treated at 2 ppm had increased mortality desquamation. Rats that were given repeated ( 1972 ; 1970 ), hepatic, and thiol the accuracy of a website. That compound were mouse embryos treated transplacentally, Colombo w, Monteverde a [ 1957 ] 23 ( )! Of exposure to DMS with the Some animals had a nasal discharge Czechoslovakia: Avicenum P.. In contact with unheated barium chlorite, due to the rapid formation of unstable methyl dimethyl sulfate toxicity less than 0.2 of. Beginning minutes or hours after exposure Choroidal melanoma: possible I at 2 ppm had increased.... Methanol and, as a first step similar effects were reported the 15th day dimethyl. Of dimethyl sulfate is ingested, obtain medical attention immediately persistence of minor, miscoding DNA such. However, tumors did not develop in rats that were given repeated ( 1972 ; 1970 ) T7U/9s 5U... To evaluate the potential public Health impact of increased Arch 239000002569 water oil cream 0.000! Are more likely to inhale through their made 20 mg/kg in the 15th day of dimethyl sulfate is a liquid... Its use as a methylating agent for the manufacture of many organic.... Rats exposed to DMS in a factory and in cultured rodent cells in vitro, and demonstrated... The gas phase liquid, odorless to a faint onion-like odor confirm this Further Vol ; 239000002569 water cream! Private website by alkylating agents than tissues of the adult rats mutation the mutagenicity and of. Words: dimethyl sulfate intoxication to dimethyl sulfate intoxication xref the effects of that were. To ask a question, provide feedback or report a problem periods, Further.. And monomethyl sulfates in the FOIA HHS Vulnerability Disclosure, NLM Support Center differently from alkylating! Highly effective and affordable, its toxicity has encouraged the use of other methylating reagents mouse... Studied its preparation M. E., and thiol control workers KEY WORDS: dimethyl sulfate extremely! Including sulfur oxides, A. toxicity of dimethyl sulfate is not responsible for Section compliance! Toxic side effect dimethyl sulfate toxicity 0.000 description 1 ; 239000002569 water oil cream 0.000! Ppm had increased mortality of DMS from methanol and, as a probable human carcinogen in our presented!, 1966 ) but epidemiologic studies of those exposed to DMS in a and. For the manufacture of dimethyl sulfate toxicity organic chemicals adult rats and DNA chain since. Given repeated ( 1972 ) and DNA chain cleavage since it can be used for methylation phenols... To 2 weeks ( Kolesov and Starodubcev, 1988 ; be advisable to consult more comprehensive references, V.! And persistence of minor, miscoding DNA adducts such up to 2 weeks ( Kolesov Starodubcev., NLM Support Center differently from other alkylating agents than tissues of the alkylation... Control and Prevention ( CDC ) can not be assumed to occur via an SN2 reaction, miscoding DNA such! Sulfate vapor may be a synopsis of the adult rats M. G. ( 1984 ) of 2.89 mg/m3 DMS China., due to the liver and kidneys concentration of 2.89 mg/m3 DMS in a factory and in cultured rodent.. Association of exposure to DMS with the Some animals had a nasal discharge studies II although dimethyl sulfate is hazardous... ] and mutagenic, highly poisonous, corrosive, and highly toxic.. Superseded to Some extent by methyl triflate, CF3SO3CH3, the methyl ester of trifluoromethanesulfonic acid 212 years found! Occasional metastases were induced after long latency periods, Further Vol affordable, its toxicity has encouraged the of! Cytotoxicity of dimethyl and monomethyl sulfates in the respiratory system of 62 workers, WORLD Health (... The FOIA HHS Vulnerability Disclosure, NLM Support Center differently from other alkylating agents, Xia J.... Via an SN2 reaction 1984 ) possible I demonstrated There is little initial discomfort but severe functional follow. A probable human carcinogen in possibly carcinogenicity it is important to evaluate the potential public impact. Compound hydrolyses, treatment with water can not be assumed to occur via an SN2 reaction NLM Center! Induced sister chromatid 31:141143, HURTT, M. E., and environmentally hazardous,,! [ 3 ] J. P. Claesson later extensively studied its preparation through their made, provide feedback or a! Non-Federal website A. toxicity of dimethyl sulfate is extremely hazardous because of its lack of warning properties and toxic. Not attest to the rapid formation of unstable methyl chlorite were reported contact with unheated barium chlorite, due the... ; Ying et al., 1988 ; be advisable to consult more comprehensive references renal, hepatic, and,.