The transcriptomic change in roots of Osndpk4 was analyzed by RNA-seq. J Biol Chem. CYTOPLASMIC. The site is secure. Herbert E, Potter VR, Takagi Y. Nucleotide metabolism. Correspondence to Eukaryote NDPKs form hexamers, including vertebrate group I enzymes like NDPK-D/NME4 [13] (Fig. This effector molecule modulates signaling of host-derived small danger molecules [ 35 , 36 ], establishing persistent infections in the host [ 37 ]. This work was supported by the Fondation pour la Recherche Mdicale (FRM; DPM20121125557), the Groupement des Entreprises Franaises contre le Cancer (GEFLUC), Cancrople IdF (n 2015-1-EMERG-25-INSERM 6-1), and a CMIRA Explora doc fellowship of the Region Rhone Alpes. Cleavage of DNA by human NM23-H2/nucleoside diphosphate kinase involves formation of a covalent protein-DNA complex. In prokaryotes, the Nm23 gene is involved in normal cell development and differentiation. Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. In the first group, one of the genes named NM23 was identified as the first metastasis suppressor protein and its gene Nm23 was less activated in metastatic cells. Characterization of the nm23-M2, nm23-M3 and nm23-M4 mouse genes: comparison with their human orthologs. However, consumption of ATP would definitely influence the cellular energy balance, which brings upon the regulation of AMP-activated protein kinase (AMPK). Plant Cell Physiol 46(8):12461254, Ding WN, Lin L, Zhang BT, Xiang XB, Wu J, Pan ZC, Zhu SH (2015) OsKASI, a -ketoacyl-[acyl carrier protein] synthase I, is involved in root development in rice (Oryza sativa L.). eCollection 2018 Mar 1. Homo sapiens (Human) Amino acids. Accessibility However, the catalytically important His118 residue is dispensible for sequence-specific DNA binding, suggesting that sequence-specific DNA recognition and phosphoryl transfer are independent properties. In hepatocarcinoma-derived cell lines, NME4 expression was lower in cell lines with high metastatic potential [61]. Product name Anti-Nucleoside-diphosphate kinase antibody See all Nucleoside-diphosphate kinase primary antibodies Description Rabbit polyclonal to Nucleoside-diphosphate kinase Host species Rabbit Tested applications Suitable for: WB more details Species reactivity Reacts with: Human Immunogen official website and that any information you provide is encrypted The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). T32-HL07343/HL/NHLBI NIH HHS/United States, NCI CPTC Antibody Characterization Program, Annu Rev Biophys Biomol Struct. , Zala D, Schlattner U, Desvignes T, et al. CL is synthesized in the inner mitochondrial membrane, leading to high CL concentrations in this membrane, while the CL content of the outer membrane is normally very low [52, 53]. Kagan VE, Jiang J, Huang Z, et al. The https:// ensures that you are connecting to the Ten paralogous genes code for the proteins NDPKs, which are separated into two groups. Dysfunctional mutation of OsNDPK4 resulted in severe defects in root development of rice. eCollection 2017 Jun. Such motifs can be also found in other CL-interacting proteins such as cytochrome c [41] and mitochondrial creatine kinase (mtCK) [42]. Antibodies used to identify and locate intracellular and extracellular proteins in common applications such as Western Blot, ELISA . Tagliazucchi L, Perea-Martinez A, Fiorini G, Manzano JI, Genovese F, Garca-Hernndez R, Pinetti D, Gamarro F, Costi MP. Plant mitochondrial nucleoside diphosphate kinase is attached to the membrane through interaction with the adenine nucleotide translocator. Epub 2018 Nov 17. Reversibility of the binding of cytochrome c to liposomes. Separate nuclear genes encode cytosolic and mitochondrial nucleoside diphosphate kinase in Dictyostelium discoideum. government site. An official website of the United States government. Ferreira-da-Silva A, Valacca C, Rios E, et al. Diseases associated with NME2 include Endometrium Carcinoma In Situ and Nemaline Myopathy 2 . National Library of Medicine An interesting structural feature of NDPK-D/NME4 is the serine residue at position 129, which is a proline in all other group I NMEs. PubMedGoogle Scholar. Nucleoside diphosphate kinases (NDPKs) are highly conserved enzymes ubiquitously found in various organisms from bacteria to human. A dysfunctional rice mutant was employed to characterize the function of OsNDPK4. Accessibility CAS Jin Ye and Wona Ding contributed equally to this paper. Moreover, after infection, Ndks released from bacteria are involved in regulating host defense activities, such as cell apoptosis, phagocytosis, and inflammatory responses. Mitochondria generate ATP, and control life and death of the eukaryotic cell. Boissan M, Montagnac G, Shen Q, et al. In enzymology, a thiamine-diphosphate kinase is an enzyme involved in thiamine metabolism.It catalyzes the chemical reaction. J Exp Bot 65(10):26332643, Thimm O, Blsing O, Gibon Y, Nagel A, Meyer S, Krger P, Selbig J, Mller LA, Rhee SY, Stitt M (2004) MapMan: a user-driven tool to display genomics data sets onto diagrams of metabolic pathways and other biological processes. OncomiR-196 promotes an invasive phenotype in oral cancer through the NME4-JNK-TIMP1-MMP signaling pathway. Our results demonstrate that OsNDPK4 plays important roles in energy homeostasis, development process, and defense responses in rice. [19], There was a lot of debate on whether NM23 gene is responsible for suppressing or activating metastasis. The immunoprecipitated NDP kinase-DNA complexes are a promising material for the detection of other specific DNA sequences interacting with NDP kinases, and showed a definite enrichment in the nuclease-hypersensitive silencer element of the PDGF-A promoter. Later, a first round of whole-genome duplication resulted in a NME3/4 gene, which was then cis-duplicated into the vertebrate NME3 and NME4 genes [21, 22]. A second gene, Nm23-H2 was soon identified [141] . FEBS Lett. nucleoside diphosphate kinase B (NDPK-B), activates TRPV5 channel activity and Ca (2+) flux, and this activation requires histidine 711 in the carboxy-terminal tail of TRPV5. 8600 Rockville Pike ndk. In most prokaryotes, the NDPK enzyme is tetrameric. Knorpp C, Johansson M, Baird AM. Also, the transfection of Nme1 into a highly metastatic melanoma line significantly reduced metastasis. Krebs HA, Wiggins D. Phosphorylation of adenosine monophosphate in the mitochondrial matrix. 1991 Jan 1;51(1):445-9 Proteomics 2(9):11311145, Sweetlove LJ, Mowday B, Hebestreit HF, Leaver CJ, Millar AH (2001) Nucleoside diphosphate kinase III is localized to the inter-membrane space in plant mitochondria. [33] reported that NME4 expression was decreased during differentiation of HL-60 cells to macrophages and neutrophils. Plant Dis Rep 57:537541, Kawasaki S, Borchert C, Deyholos M, Wang H, Brazille S, Kawai K, Galbraith D, Bohnert HJ (2001) Gene expression profiles during the initial phase of salt stress in rice. 8600 Rockville Pike ATP + nucleoside 5'-phosphate AMP + 5'-phosphonucleoside 3'-diphosphate. Cereal Res Commun 41(1):7887, Feng BH, Yang Y, Shi YF, Shen HC, Wang HM, Huang QN, Xu X, Lu XG, Wu JL (2013) Characterization and genetic analysis of a novel rice spotted-leaf mutant HM47 with broad-spectrum resistance to Xanthomonasoryzae pv. Plant Cell Rep 27(3):529534, Haque ME, Yoshida Y, Hasunuma K (2010) ROS resistance in Pisumsativum cv. J Cell Biochem. Amrein L, Barraud P, Daniel JY, Perel Y, Landry M. Expression patterns of nm23 genes during mouse organogenesis. Human NDPK-D/NME4 is ubiquitously expressed, with mRNA found at high levels in liver, kidney, bladder, prostate, at intermediate levels in heart, colon, intestine, skeletal muscle, and ovary and at low levels in brain, testis, and peripheral leukocytes [12, 30]. Annu Rev Phytopathol 55(1):401425, Blilou I, Xu J, Wildwater M, Willemsen V, Paponov I, Friml J, Heidstra R, Aida M, Palme K, Scheres B (2005) The PIN auxin efflux facilitator network controls growth and patterning in Arabidopsis roots. Furthermore, NDPK is involved with the signal transduction processes and G protein-coupled receptor endocytosis as it transfers a phosphate group onto the G -subunits and convert GDP to GTP. Cite this article. 2017;135:88197. Chem Phys Lipids 2014;179:3241. Chu CT, Ji J, Dagda RK, et al. Article The GABA transaminase, ABAT, is essential for mitochondrial nucleoside metabolism. The human nm23-H4 gene product is a mitochondrial nucleoside diphosphate kinase. 1) and is unique to the NDPK-D/NME4 isoform. Endocrinology. Clipboard, Search History, and several other advanced features are temporarily unavailable. To be or not to be a nucleoid protein: a comparison of mass-spectrometry based approaches in the identification of potential mtDNA-nucleoid associated proteins. Plant Cell 23(9):33353352, CAS Arch Biochem Biophys. Please enable it to take advantage of the complete set of features! The gene encoding nucleoside diphosphate (NDP) kinase of Escherichia coli was identified by polymerase chain reaction using oligodeoxyribonucleotide primers synthesized on the basis of consensus sequences from Myxococcus xanthus and various eukaryotic NDP kinases. Please enable it to take advantage of the complete set of features! Adaptation; Bacteria; Bacteria and host interactions; Nucleoside diphosphate kinase; Nucleotide metabolism; Virulence. 2002;444:30623. These proteins go about interrupting metastasis by binding metastasis-promoting proteins. 1). Please enable it to take advantage of the complete set of features! Among its related pathways are purine nucleotides de novo biosynthesis and pyrimidine deoxyribonucleotides biosynthesis from CTP . Nucleoside diphosphate kinase 7. 2021 Aug;63(8):719-731. doi: 10.1007/s12033-021-00338-3. FOIA Accessibility The authors have no conflict of interest to declare. Many NDP serve as acceptor while NTP are donors of phosphate group. Mol Cancer 2014;13:218. Bookshelf However, the resistance of Osndpk4 against bacterial blight was significantly enhanced. NCBI Full Gene Name NME/NM23 nucleoside diphosphate kinase 2; NCBI Gene Aliases NM23-H, NM23-H2, NM23B, nm23-M, nm23-M2; Conjugate/Tag/Label GFPSpark; Add to Compare List. Identification of residues involved in serine phosphorylation and oligomerization. The .gov means its official. Hasunuma K, Yabe N, Yoshida Y, Ogura Y, Hamada T. J Bioenerg Biomembr. Nat Protoc 7(3):562578, Tsukagoshi H, Busch W, Benfey PN (2010) Transcriptional regulation of ROS controls transition from proliferation to differentiation in the root. 2014;9:e89916. Other gene names. 1988;80:2004. A novel human nucleoside diphosphate (NDP) kinase, Nm23-H6, localizes in mitochondria and affects cytokinesis. The .gov means its official. Science. 1993;129:1416. Epub 2018 Feb 7. Lacombe ML, Milon L, Munier A, Mehus JG, Lambeth DO. 2002;13:44955. PubMed Central Defense responses; Nucleoside diphosphate kinases (NDPKs); RNA-seq; Rice; Short root. Buczynski G [15] In addition to signaling, NDPK is involved in controlling K+ channels, cell secretion, and cellular energy production. Epand RF, Schlattner U, Wallimann T, Lacombe ML, Epand RM. . An official website of the United States government. Google Scholar, Dorion S, Rivoal J (2015) Clues to the functions of plant NDPK isoforms. MeSH 2015;10:e0122308. In our hands, no nuclear NME4 has been observed in various human cell lines, even when overexpressed. Nucleoside diphosphate kinase A (NDPK-A), encoded by the nm23-H1 gene, acts as a metastasis suppressor . A R90 equivalent is also absent in the sequences of other human NME protein sequences, and replaced by acidic residues in NDPK-A, -B, and -C (NME1, 2, and 3). 174,175 Among these, NM23-H2 is Organism. Anderca MI, Furuichi T, Pinontoan R, Muto S. Identification of a mitochondrial nucleoside diphosphate kinase from the green alga Dunaliella tertiolecta. 2022 Jun 30;13:919633. doi: 10.3389/fmicb.2022.919633. -, Plant J. Plant Physiol 136(2):30343042, Kano A, Gomi K, Yamasaki-Kokudo Y, Satoh M, Fukumoto T, Ohtani K, Tajima S, Izumori K, Tanaka K, Ishida Y, Tada Y, Nishizawa Y, Akimitsu K (2010) A rare sugar, d-allose, confers resistance to rice bacterial blight with upregulation of defense-related genes in Oryza sativa. The site is secure. 2022 Aug 16;22(1):198. doi: 10.1186/s12866-022-02612-z. . HeLa cells expressing the wild-type NDPK-D/NME4, in contrast to those expressing the R90D mutant, were sensitized to rotenone-induced apoptosis [35]. Nat Protoc 2(10):23482353, Moon H, Lee B, Choi G, Shin D, Prasad DT, Lee O, Kwak SS, Kim DH, Nam J, Bahk J, Hong JC, Lee SY, Cho MJ, Lim CO, Yun DJ (2003) NDP kinase 2 interacts with two oxidative stress-activated MAPKs to regulate cellular redox state and enhances multiple stress tolerance in transgenic plants. https://doi.org/10.1007/s00425-020-03355-9. Strategies that aim at favoring or protecting NDPK-D functions may have preventive or therapeutic potential for numerous human pathologies. The https:// ensures that you are connecting to the Proteomics 5(8):21402156, Love MI, Huber W, Anders S (2014) Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Metatranscriptomics captures dynamic shifts in mycorrhizal coordination in boreal forests. [72]). A Pelota-like gene regulates root development and defence responses in rice. Citations: . sharing sensitive information, make sure youre on a federal Sweetlove LJ, Mowday B, Hebestreit HF, Leaver CJ, Millar AH. Google Scholar. CAS 2015;21:41727. This site needs JavaScript to work properly. Milon L, Rousseau-Merck MF, Munier A, et al. Such specific appearance of CL at the mitochondrial surface has been suggested as a signal for triggering apoptosis [54] or mitophagy [55], but underlying molecular mechanisms remained elusive. MacVicar T, Langer T. OPA1 processing in cell death and disease - the long and short of it. The ndk gene appears to be in a monocistronic operon and, when cloned in a pUC vector, NDP kinase was overproduced at a level of approx. Lacombe ML, Milon L, Munier A, Mehus JG, Lambeth DO. However, outer membrane CL is selectively increased in mitochondria isolated from HeLa cells over-expressing the wild-type NDPK-D/NME4 but not the membrane binding-deficient mutant (R90D), while phosphatidylcholine distribution remains unchanged [35]. Biochem J. [1] Other activities include cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor, endocytosis, and gene expression. In sporadic breast cancers, loss of heterozygosity, or allelic imbalance, associated with nodal metastases, was observed in the NME4 gene region [62]. 2010;64:1339. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate, and synthesize products such as UTP. Ndk, a novel host-responsive regulator, negatively regulates bacterial virulence through quorum sensing in Pseudomonas aeruginosa. Map-based cloning identified that the mutation occurred in the OsNDPK4 gene. Biochim Biophys Acta. The NDPK-D/NME4 fusion constructs used in these experiments with mouse neuroblastoma cells carry an N-terminal acidic myc-tag just preceding the basic mitochondrial targeting sequence, which could disturb the mitochondrial import mechanism. J Biol Chem. Nature 438(7070):10131016, Chen S, Jin W, Wang M, Zhang F, Zhou J, Jia Q, Wu Y, Liu F, Wu P (2003) Distribution and characterization of over 1000 T-DNA tags in rice genome. Plant Cell Physiol. FEBS Lett 508(2):272276, Takatsuka H, Umeda M (2014) Hormonal control of cell division and elongation along differentiation trajectories in roots.
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